Table 1 also shows many genes related to metal protein were up-regulated in severe AD including CAMK2B, CALM1, CAPZA2, CHGB, LOC728320/LTF, MPPE1, MT1F, MT1M, SCGN, ZIC1, ZBTB20, ZNF500, ZNF580, ZNF652, ZNF710, SLC24A3 and SLC7A11. This evidence concerns the gene MPPE1 and Alzheimer disease.