FOXP3 and systemic lupus erythematosus: Both the FOXP3 rs12843496 SNP and the intron 0 marker, located in the promoter/enhancer region of the gene, were nominally associated with SLE (χ2 = 6.14, P = 0.013 and χ2 = 10.30, P = 0.036, respectively) (Table 3).