PIK3CA and ovarian carcinoma: In many human tumors, including epithelial ovarian cancer [23], [25], [26], [27], [28], [29], [30], PIK3CA activation is a critical oncogenic event and can be mediated by multiple genetic/genomic alterations such as gene copy number amplification [23], gain of functional mutations [24], and transcriptional up-regulation [33], [34], [35].