MAGEL2 and Infertility: Intriguingly, it has been shown that protein restriction during neonatal development can impair adult fertility by delaying puberty and accelerating reproductive decline in female rats [22], so it is possible that the early failure-to-thrive seen in Magel2-null pups contributes to both their delay in puberty and their later reproductive difficulties, but is unlikely to be the sole cause of infertility.