On multivariate analysis, only increased EGFR expression (protein or RNA), the presence of metastasis and/or recurrence, a high tumor grade (GII &GIII) and a combination of aberrant markers (≥ 2) were significantly associated with reduced OS rates (p = 0.022&0.025, p = 0.000, p = 0.001, p = 0.001). This evidence concerns the gene EGFR and neoplasm.