CCL20 and S100P were significantly up-regulated in HepG2 but not in HCC data, while ZFYVE1, PEG10, SGCE, XAGE-1, COL4A1, ZNF83, TNPO2 and TM4SF1 were up-regulated in HCC data. The gene discussed is COL4A1; the disease is hepatocellular carcinoma.