Mutations in MFRP have been identified to be responsible for nanophthalmos 2 (NNO2, OMIM 609549) and microphthalmia (OMIM 611040), where extremely high hyperopia (+8.00 D-+25.00 D) is a prominent sign [6,8,14]. The gene discussed is MFRP; the disease is nanophthalmos 2.