C2 and age-related macular degeneration: We also found no interaction (p=0.68–0.98) between rs2511989 and other major genetics risks for AMD including complement factor H (CFH, Y402H), ARMS2/HTRA1 (tagging SNP A69S), complement components CFB/C2 (CFB, L9H; C2, rs547154), and C3 (R102G and P314L).