[42], [43] CF gene knockout mice, whose main pathology is intestinal mucous obstruction, have increased fucosylation and increased FUT2 expression.[44] In a small study of homo- and heterozygous ΔF508 patients, presence of both functional secretor and Lewis genes was associated with meconium ileus. [45] These studies lead us to hypothesize that MI in CF patients may be related to glycosylation patterns/ABH status; however, no difference in prevalence of ABH genotypes was found between the two groups. This evidence concerns the gene FUT2 and Meconium ileus.