[23] FUT 3 alleles were successfully determined at these four loci for 707 patients. There was no significant difference for individual SNPs between mild versus severe lung disease patients, nor by gender, meconium ileus or asthma status by Fisher exact test. (See Table 2). Orntoft et al correlated FUT3 gene mutations with enzyme activity and circulating levels of sialyl-Lewis a [28]; therefore, the SNPs were analyzed in groups consistent with Lewis negative or positive phenotypes, but no significant differences were observed. (Data not shown). [23]. Here, FUT3 is linked to intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency.