In two pancreases from patients with type II diabetes butnone of the nondiabetic controls, there were two distinct types of islets,exhibiting a 3.5-fold difference in the level of insulin expression in the β-cells.Interestingly, β-cateninupregulation was present to a much greater degree in β-cellswith diminished insulin expression (Figures 5(a)–5(e)). This evidence concerns the gene INS and type 2 diabetes mellitus.