MYC and type 2 diabetes mellitus: A well-studied member of that group is c-myc [29].Strikingly, c-myc was expressed in the islets from pancreases from patientswith type II diabetes, but not in islets from nondiabetic individuals (Figures 2(p)–2(s)).Despite the role of c-myc in promoting cell proliferation, no increase in isletcell proliferation was observed, as measured by Ki67 staining (data not shown).In addition to c-myc, cyclinD1 is an important regulator of proliferation thatis induced by Wnt signaling [30].It was also highly upregulated in the islets of type II diabetic patients (Figures2(k)–2(o)).