CASP2 and Miyoshi myopathy: The cytokine mixtures induced up and down regulation of several genes for proteins involved in control of apoptosis (Table 1) including caspase 2, downregulated -3 fold, p < 0.05 by both MM and Th2 cytokines, and caspase 7, downregulated -3 fold by Th1 and MM cytokines.