Consistent with the observations in CHO-APPswe cells, using activity assays as discussed above we confirmed that viral expression of exogenous h-S100A7 expression in primary neuron cultures derived from Tg2576 embryos promotes cellular α-secretase activity coincidental with significant attenuation of accumulation Aβ1–40 and Aβ1–42 peptide content in the conditioned medium 48 hrs after infection, relative to Lac-Z infected neurons (Fig. 5A–C). Here, S100A7 is linked to infection.