ADAM10 and Alzheimer disease: Although the mechanisms leading to reduction of ADAM-10 in circulating platelets in AD is presently not known, in view of the activity of ADAM-10 as an α-secretase, it is conceivable that the presence of lower levels of ADAM-10–mediated “non-amyloidogenic” α-secretase activity in peripheral cells such as circulating platelets could eventually contribute to amyloid neuropathogy in AD.