ADAM15 and Hyperglycemia: After hyperglycemia treatment, the change in expression of most proteins was 2 fold: densitometry of the blots displayed in Figure 2 detected a fold change decrease of 1.9 for MMP2, decrease of 2.7 for ADAM15, increase of 2 for ST14, and decrease of 1.9 for Pcsk1 in the HG group.