ERBB2 and gastric carcinoma: Furthermore, in our consecutive series of gastric cancer patients, we found ERBB2 amplification in two early gastric carcinomas (stage IA), as reported earlier in similar studies (David et al, 1992; Ooi et al, 1998; Park et al, 2006; Kim et al, 2007), further supporting the idea that ERBB2 amplification may occur at an early stage in gastric carcinogenesis.