Earlier studies have shown that the orally available MEK inhibitor CI-1040 enhances the efficacy of paclitaxel in lung cancer xenograft models (McDaid et al, 2005), and that the MEK inhibitor AZD6244 enhances the pro-apoptotic effects of docetaxel in human melanoma cells (Haass et al, 2008). The gene discussed is MAP2K7; the disease is lung carcinoma.