VHL and colorectal carcinoma: In CRC, epigenetic silencing of multiple TSGs has been reported frequently, including MLH1, p16INK4A, MGMT, VHL, APC, RASSF1A, HIC1, CHFR, ADAMTS18 and PCDH10 in various percentages of CRC tumours (Herman et al, 1998; Esteller et al, 2001; Kim et al, 2005; Ying et al, 2006; Jin et al, 2007 ).