EGR1 has been shown to mediate apoptosis in a number of malignancies (Pignatelli et al, 2003; Yu et al, 2007), possibly by activating the transcription of pro-apoptotic genes such as PTEN, and EGR1 can also block angiogenesis and tumour invasion (Lucerna et al, 2006; Yu et al, 2007). The gene discussed is PTEN; the disease is neoplasm.