However, this and other early clinical observations were later overshadowed by frequent findings of thrombosis associated with positive anti-CL (aCL) test, leading to recognition of the aPL syndrome (APS) in the 1980s by Harris et al [3,4] and by Hughes et al [5], originally called anticardiolipin (aCL) syndrome, now sometimes Hughes' syndrome. This evidence concerns the gene ACLY and Venous thrombosis.