IL6 and coinfection: The increased levels of interleukin 6 associated with HIV infection; and the clonal expansion of plasma cells caused by co-infection with other viruses (Epstein-Barr virus, human herpes virus-8) observed in HIV-seropositive subjects, are some possible mechanisms that are implicated in the evolution of B cell neoplasms and the development of myeloma in HIV-seropositive subjects [29,30,35].