While most of the TRIP-Br family members have recently been extensively characterized and shown to be involved in a variety of important cellular processes including E2F-mediated cell cycle progression, p53-dependent stress response and cancer pathogenesis [6,7,9,11,18,20-22], the physiological role of TRIP-Br2 in mammalian cells remains poorly understood and its direct link to cancer pathogenesis has not been established. This evidence concerns the gene TP53 and cancer.