INS and type 2 diabetes mellitus: Sensitivity analyses showed that the magnitude of improvement in HbA1c was greatest in patients with the poorest glycaemic control (mean adjusted decreases of 0.57 and 1.07% in type 1, and 0.47 and 0.97% in type 2 diabetes patients with baseline HbA1c levels ≥ 8% and ≥ 10%, respectively) (Table 2), and comparable with that reported in trials of patients newly commencing insulin therapy [32].