Of the 291 HEV71-positive children, 104 (36%) had mild HFMD, 73 (25%) had HFMD-Non-CNS, 114 (39%) had HFMD-CNS (22 had ASM, 83 had encephalitis, 2 had encephalitis associated with AFP, 7 had encephalitis associated with cardiorespiratory failure). Here, AFP is linked to aggressive systemic mastocytosis.