In contrast, achievement of 98 bp amplification products for 20 out of 45 tumor tissues points out that 44.4% of tumor tissues are methylated either in one or both alleles of APC. Among methylated tumor tissues, 13 were heterozygous for the APC promoter; for which both 111 bp and 98 bp products were observed (Figure 4). The gene discussed is APC; the disease is neoplasm.