Another study showed that 71% of neuroendocrine carcinomas of the cervix had lost BRG1 expression [13] and BRG1 has been implicated in breast cancer through its role in estrogen receptor dependent transcription [35], its interaction with the breast cancer susceptibility gene BRCA1 [27] and because BRG1 haploinsufficient mice are prone to mammary tumors [23]. The gene discussed is ESR1; the disease is breast carcinoma.