Thoughan acute bout of physical activity is accompanied by responses that in manyrespects are similar to those induced by infection and sepsis, there are someimportant differences in the cytokine response to exercise from that elicitedby severe infection [27, 60, 61].The striking difference between exercise and sepsis with regard to cytokineresponses is that the classical proinflammatory cytokines, TNF-α and IL-1β, ingeneral do not increase with exercise. The gene discussed is TNF; the disease is Sepsis.