All 20 of these are disease-causing polypeptides in POAG and all have mutations in the olfactomedin domain of MYOC implying that the integrity of this domain is necessary for proper folding and that interference of MYOC export due to mutations in the olfactomedin domain may result in intracellular accumulation of misfolded proteins [9]. The gene discussed is MYOC; the disease is open-angle glaucoma.