Evolutionary conservation of the UPR together with previous reports that implicate this pathway in the etiology of glaucoma in human trabecular meshwork cells [9], [12], [14] support the notion that comparative genomics and proteomics studies that utilize the Drosophila model may provide new insights into conserved cellular pathways that are associated with human ocular hypertension and glaucoma, such as identification of genetic modifiers of MYOC-induced cellular stress. Here, MYOC is linked to glaucoma.