Suppression of constitutive NF-κB activation by I3C in HTLV-1-infected T-cell lines is consistent with previous reports, which showed the suppression of constitutive NF-κB in PC3 prostate cancer cells, MDA-MB-231 breast cancer cells and acute myelogenous leukemia cells [37-39]. Here, NFKB1 is linked to prostate cancer.