Upon closer examination of the results for HLAC from individual donors, we noted that while HIV-1Δnef depleted CD4+ T lymphocytes less vigorously than an average infection with wt HIV-1 in essentially all experiments (Fig. 2A, C), p24 production by HIV-1Δnef reached levels in the range of the highest ones obtained with wt HIV-1, in some, but not all experiments (Fig. 2B). The gene discussed is CD4; the disease is infection.