The proteins of these ECM genes have previously been documented in POAG in the lamina cribrosa, e.g., collagen type I (COL1A1; +0.6 SLR), collagen type V (COL5A1; +0.5 SLR) and collagen type XI (COL11A1; +0.5 SLR). The gene discussed is COL5A1; the disease is open-angle glaucoma.