SPARC and open-angle glaucoma: Notable also were ECM genes or ECM modulating genes not classically associated with POAG changes in the optic nerve head such as tissue inhibitor of matrix metalloproteinase-3 (TIMP-3; +1.3 SLR), decorin (DCN; −0.9 SLR), versican (VCAN; +1.2 SLR), lysyl oxidase (LOX; +0.7 SLR), and secreted acid protein cysteine rich (SPARC; +1.1 SLR).