Upregulated genes in POAG LC cells included, transforming growth factor beta 1 (TGFβ1), secreted acid protein cysteine rich (SPARC), periostin (POSTN), thrombospondin-1 (THBS1), cartilage linking protein-1 (CRTL-1), and collagen type I  (COL1A1), collagen type V (COL5A1), and collagen type XI (COL11A1). Here, HAPLN1 is linked to open-angle glaucoma.