Among the 25 most upregulated genes in POAG LC cells were periostin (POSTN; +3.0 SLR), cartilage linking protein 1 (CRTL-1; +1.8 SLR), dystrophin (DMD; +2.0 SLR), Rho GDP dissociation inhibitor beta (ARHGDIB; +1.1 SLR), sulfatase 1 (SULF1; +1.1 SLR), thrombospondin-1 (THBS1;0.8 SLR), and bone morphogenetic protein-1 (BMP-1; +0.7 SLR). Here, HAPLN1 is linked to open-angle glaucoma.