MDR analysis identified a best 6-factor model for POAG: MYOC IVS2+35A>G, OPTN Met98Lys, OPTN IVS5+38T>G, OPTN IVS8–53T>C, WDR36 IVS5+30C>T, and APOE −491A>T. The gene discussed is APOE; the disease is open-angle glaucoma.