OPTN and open-angle glaucoma: So far, at least 22 genetic loci had been linked to POAG [2-4], and three genes have been identified for POAG from the reported loci, myocilin (MYOC, OMIM 601652) [5,6], optineurin (OPTN, OMIM 602432) [7,8], and WD repeat-domain 36 (WDR36, OMIM 609669) [9].