In the Chinese population of Hong Kong, Fan et al. [11] detected three pairs of statistical interactions for normal tension glaucoma (between MYOC −83G>A and the APOE ε2/ε3/ε4, MYOC IVS2+35A>G and APOE −219T>G, as well as OPTN Arg545Gln and APOE ε2/ε3/ε4)) and two pairs of interactions for POAG (between MYOC Thr353Ile and OPTN IVS15+10G>A and between OPTN IVS5+38T>G and APOE −491A>T). The gene discussed is OPTN; the disease is open-angle glaucoma.