We found that the local (i.n.)administration of the low dose of DTx to DTR mice immediately prior to i.n. influenza infection resulted in the preferential elimination of the two CD11chi DC subsets, the MHC IIhi CD103+ and CD11bhi RDC from the respiratory tract (Fig. 3D) and also inhibited the accumulation of the CD103+ and CD11bhi DC subsets in the MLN after infection, with only a modest effect on Gr-1+ MoDC accumulation (Fig. 3E and Fig. S6B). The gene discussed is ITGAE; the disease is influenza.