CCR7 and viral infectious disease: Although Gr-1+ MoDC had been implicated as important APC for naïve T cell activation in several models [12], [13], [14], our findings on the impact of low dose i.n. DTx administration (as well as CCR7 deficiency) on the numbers and migration of these inflammatory DC to the MLN during infection suggest a minor role for these cells as APC at least in the respiratory tract during natural virus infection.