In a sample of 12 women with bulimia nervosa, 15 women with anorexia nervosa, and 15 healthy women, a significant increase in plasma AEA was reported in both bulimic and anorexic patients compared with controls; leptin concentrations were significantly inversely correlated with AEA concentrations in both anorexic patients and healthy controls [18]. This evidence concerns the gene LEP and anorexia nervosa.