To investigate the possible role of activating FcγR in human LN, we examined the expression of FcγRI/CD64, FcγRIII/CD16 and FcγRII/CD32 on circulating monocytes from SLE patients, and the relationship of FcγR expression levels to renal involvement and chemokine production. This evidence concerns the gene FCGR1A and systemic lupus erythematosus.