The markedly elevated expression of FcγRI/CD64 among SLE patients with LN (Figure 1b) may serve as a surrogate marker of renal disease that correlates with both established measures of renal dysfunction (increased serum creatinine, blood urea nitrogen, and proteinuria) and inflammation (elevated serum CRP, C3 deficiency). The gene discussed is FCGR1A; the disease is systemic lupus erythematosus.