To investigate the possible role of activating FcγR in human LN, we examined the expression of FcγRI/CD64, FcγRIII/CD16 and FcγRII/CD32 on circulating monocytes from SLE patients, and the relationship of FcγR expression levels to renal involvement and chemokine production. The gene discussed is FCGR3A; the disease is systemic lupus erythematosus.