CD14 and systemic lupus erythematosus: While the frequencies and absolute numbers of CD16+CD14+ monocytes were similar between SLE patients and control individuals, the intensity of CD16 staining was increased slightly in SLE patients with or without LN (12 ± 0.4 and 13 ± 0.6, respectively, versus control individuals 10 ± 0.6; both P < 0.01, Student's t test) (Figure 1d and Table 2).