Trp2180–188, a known H2-Kb-restricted melanoma tumor antigen shared by glioma tumors such as GL26 cells [47,48], also induced proliferation of T lymphocytes from glioma-bearing mice treated with Flt3L and TK (*, p < 0.05 versus saline; η2 = 0.43; Figure 1E) confirming that clonal expansion of T lymphocytes against a specific glioma antigen occurs in response to treatment. The gene discussed is FLT3LG; the disease is central nervous system cancer.