Other investigators have used different polycolonal antibodies raised against small peptides within Box A [39,77] or Box B [78–80] of HMGB1 to successfully inhibit HMGB1 activity in animal models of collagen-induced arthritis, sepsis, liver ischemia reperfusion injury, and intestinal barrier dysfunction following hemorrhagic shock. The gene discussed is HMGB1; the disease is Sepsis.