Given that PGC-1α acts as a transcriptional coactivator for PPARγ, thus regulating many physiological processes [13]–[15], we hypothesized that the downregulation of PGC-1α by glucose may play a role in an in vitro-model of VSMC proliferation and migration induced by hyperglycemia. The gene discussed is PPARGC1A; the disease is Hyperglycemia.