MAPK1 and cancer: In the MCF10A ductal cells, once phosphorylated ERK and akt mRNA were boosted by upregulated mitogenic input, and their normal-like behaviour changed to mimic that of the BT474 and SKBR3 cancer cells, loss of akt mRNA resulted in an intensity of apoptotic death similar to that of the BT474 and SKBR3 cells where ErbB2 is overexpressed.