Larger and longer term studies on the effect of GH replacement in Alström syndrome patients are encouraged, to assess if the substitution therapy with Recombinant Growth hormone is cost-effective and without risk in such patients with Alström Syndrome and severe insulin resistance, knowing that the state of GH deficiency seen in Alström syndrome renders these patients exposed to a lifelong risk of metabolic disturbances. This evidence concerns the gene GH1 and Alstrom syndrome.