These results indicate that MassARRAY is a powerful tool for detection of methylation of CpG sites, and screening of the DNA methylation status of MUC1 and MUC4 genes by MassARRAY analysis of discharged fluids, such as pancreatic juice, bile or sputum is likely to be of value for early detection of pancreatobiliary and lung carcinomas. Here, MUC1 is linked to lung carcinoma.