AKT1 and neoplasm: Several tumour types that display sensitivity to paclitaxel also show activation of the PI3-kinase/Akt/mTOR signalling pathway (Shayesteh et al, 1999; Hu et al, 2000; Perez-Tenorio et al, 2002; David et al, 2004; Samuels et al, 2004; Saal et al, 2005).