AKT1 and cancer: In cancer cells, inhibition of the PI3-kinase/Akt/mTOR signalling pathway (Hu et al, 2002; Yu et al, 2005), including inhibition of mTOR with rapamycin, was shown to counteract Akt-mediated resistance to drugs inhibiting tubulin (Vanderweele and Rudin, 2005) and to restore apoptosis (Faried et al, 2006).