CASP3 and colorectal cancer: The two step real time PCR results revealed that the caspase 3 transcripts increased in the time dependent manner in the HT 29 colorectal cancer cells treated with cisplatin and oxaliplatin but caspase 3 transcripts levels decreased in the time dependent manner in the cells treated with cisplatin and oxaliplatin with doxycycline (p = 0.01 and p = 0.005) (figure 3).