rs1570538 has been shown to be weakly associated with multiple sclerosis in our previous study of IL2RA/MS in a cohort of 346 cases and 413 controls (allelic P-value = 0.04) [10] and showed here increased statistical significance with our actual extended cohort (allelic association P = 0.033; OR for minor allele = 0.86, 95% CI, 0.75–0.99; genotype association (Cochran-Armitage trend test P = 0.033). Here, IL2RA is linked to multiple sclerosis.