PPARD and colitis: So far, the benefits of PPARβ/δactivation in colitis are poorly documented [44].One report suggested that PPARβ/δ-null mice exhibit more severe damage in a model ofDSS-induced colitis, whereas a PPARβ/δ agonist had no protective or deleterious effectwhen administrated to PPARβ/δ-wt or -null animals [123].