TNF-α and IL-6 plasma levels were alsosimilar between the NGT and the DM2 women of our study, although their levelsare significantly increased in the subgroup of DM2 women with BMI > 27,compared to NGT with BMI < 27 women; moreover, they were significantlycorrelated with the obesity and insulin resistance indices. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.