TNF and Insulin resistance: Thus, in type 2 diabetes, macrophages that infiltrate the stroma of theadipose tissue and/or the vascular endothelium can locally produce and secrete increasedresistin and cytokine (Il-1β, TNF-α, and IL-6) levels, which may enhance theinflammatory load and the associated insulin resistance and vascular dysfunctionobserved in these patients.