Circulating Il-1β did not differentiate between thehealthy control and the DM2 women, a result that lines with previous studies inwhich Il-1β alone cannot associate with the risk of developing type 2 diabetes,while Il-1β was even decreased in an impaired glucose tolerance (IGT) groupcompared to NGT subjects [37, 38]. This evidence concerns the gene IL1B and type 2 diabetes mellitus.