Although in vitro and in vivostudies demonstrate a role for PPARγ in modulating growth and differentiation ofhuman colon cancer cell lines [27], thiazolidinedione treatment with rosiglitazone(BRL49653) or troglitazone stimulated rather than inhibited the development ofcolon tumors in APCmin/+ mice [48, 49]. The gene discussed is PPARG; the disease is malignant colon neoplasm.