MCAM and breast cancer: Two subgroups of human mammary cancer cell lines were easily distinguishable on the basis of CD146 expression (Figure 5): MCF-7, ZR-75-30, BrCA-MZ-02, MDA-MB-453 and T47-D cell lines, which display epithelial characteristics, expressed CD146 at low levels (CD146-); and oppositely, MDA-MB-231, Hs578T, Sum159PT, MDA-MB-436 and BT-549 cell lines, which display mesenchymal characteristics, also expressed high levels of CD146 (CD146+).