At day 4 following CB4 infection of WT NOD mice, we observed significant increases compared to uninfected controls in the levels of both TNF-α (Figure 5A) and IL-6 (Figure 5B) and to a lesser extent IFN-γ (Figure 5C) Little to no production of IL-4, IL-5, IL-10, IL-12p70 was observed following infection (data not shown). The gene discussed is IFNG; the disease is infection.