CD40, IL12B, prostaglandin E synthase, C-type lectin domain family 4 member E, and TNFα-induced protein 6 were upregulated, while CD1C, IFIT1, IFIT3, OAS1, and IL8RA were downregulated upon TNF stimulation in both SLE patients and healthy individuals. The gene discussed is CD40; the disease is systemic lupus erythematosus.