In an extension analysis [15] using data from 12,360 subjects previously reported and new data from 11,019 unrelated MS subjects, 13,616 controls and 2,811 trio families (8,433 individuals) from across Europe, the association for MS risk at the two IL2RA variants became unequivocal (rs12722489, OR = 0.81 (95% c.i. 0.77–0.85), P = 2.24×10−15; relative risk, RR,  = 0.81 (95% c.i. 0.72–0.91), P = 5.47×10−4; rs2104286, OR = 0.80 (95% c.i. 0.77–0.84), P = 2.38×10−23; RR = 0.78 (95% c.i. 0.71–0.86)). This evidence concerns the gene IL2RA and myeloid sarcoma.