Given previous studies showing that NPY levels are higher in cardiovascular disease [16],[31] (findings that were corroborated in our study), and the strong concordance of our results showing a higher frequency of the rs16147 G allele in CAD cases, it follows that the G allele would result in increased NPY expression, as observed in the previous NPY studies [23],[24] and in our study. This evidence concerns the gene NPY and cardiovascular disorder.