In this analysis, the association of rs16147 with CAD remained significant in our comparison of GENECARD probands with CATHGEN controls (genotype OR 1.60 [95% CI 1.11–2.31], p = 0.01; allele OR 2.00 [1.11–3.59], p = 0.03), suggesting that NPY genotype contributes to CAD risk independently of traditional risk factors, at least in family-based cohorts. The gene discussed is NPY; the disease is coronary artery disorder.