Table S3 lists risk factors significant in the multivariable model for the SNP remaining significant after adjustment (rs16120), demonstrating the independent strength of effect of genotype, as well as those for intermediate risk factors, in a full fitted model. Neither BMI nor cholesterol levels varied significantly by NPY genotype (data not shown). Thus, it appears that NPY SNPs may contribute to atherosclerosis risk either independently of traditional risk factors, especially in high-risk families, or via mechanisms that may relate to dyslipidemia in non-familial CAD. Here, NPY is linked to metabolic syndrome.