We also related the variations 1784G>C and 2386A>G in the interacting domains of the SREBF-2 and SCAP genes to the areas of the different types of atherosclerotic lesions in the coronary arteries and to the risk of sudden cardiac death (SCD) and acute myocardial infarction (AMI) in an autopsy series of 300 Finnish men included in the Helsinki Sudden Death Study (HSDS). This evidence concerns the gene SCAP and sudden cardiac arrest.