The limitations of our study include the two distinct sample materials we used: The vascular samples collected from elective patients subjected to open vascular surgical procedures were used for the SREBF-2 and SCAP mRNA expression study, and the HSDS samples were used for the association study between SREBF-2 1784G>C as well as SCAP 2386A>G and coronary atherosclerosis. The gene discussed is SCAP; the disease is coronary atherosclerosis.