Carriage of the SREBF-2 C allele and the SCAP G allele was associated (OR 2.68, 95% confidence interval [CI] 1.07–6.71, p = 0.035) with an increased risk of SCD when compared with subjects carrying the SREBF-2 C allele and those with the SCAP AA genotype (Table 3). Here, SREBF2 is linked to Schnyder corneal dystrophy.